Ji-Yen Cheng 鄭郅言
Associate Research Fellow/ BioMAps BioMicrofluidic Applications Laboratory

Ways to contact me:

Phone:886-2-2789-8000 ext 34
Fax: 2782-6680
Address: Research Center for Applied Sciences, Academia Sinica
128 Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan, ROT


Adjunct Positions:
Dept. Mech. Mechatronic Eng., National Taiwan Ocean Univ. Taiwan, ROT
Inst. of Biophotonics, National Yang-Ming Univ. Taiwan, ROT




Research Fields:

  • Cell-based micro analysis:cell migration in weak DC EF, cell-cell interaction co-culture chip, cellular chemotaxis, electrotaxis and metastasis, affinity binding and separation.
  • Rapid prototyping of microfluidic biochip and their biomedical applications.
  • Microarray technologies: flexible in-situ array synthesis, rapid hybridization, mRNA labeling chip, and portable DNA amplification chip.
  • Laser micromachining – mechanism and applications.

Recent Publications:

  1. Microfluidic ARray Synthesizer (MArS) for Rapid Preparation and Hybridization of
    Custom DNA Microarray Ji-Yen Cheng* and Huai-Yi Chen, Biotechnology and Bioengineering, 2009, V104, p400
    [ DOI:10.1002/bit.22383 ]
  2. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng* and C.-H. Lee*, "Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip ", Lab on a Chip, 9, 884-890.(2009)
    [ DOI:10.1039/b814405b ]
  3. C.-W. Huang, J.-Y. Cheng*, M.-H. Yen and T.-H. Younga, "Electrotaxis of lung cancer cells in a multiple-electric-field chip", Biosensors and Bioelectronics, 24, 3510-3516.(2009)
    [ DOI:10.1016/j.bios.2009.05.001 ]
  4. L.-C. Hsiung, C.-H. Yang, C.-L. Chiu, C.-L. Chen, YuehWang, H. Lee, J.-Y. Cheng, M.-C. Ho and A. M.Wo*, "A planar interdigitated ring electrode array via dielectrophoresis for uniform patterning of cells", Biosensors and Bioelectronics, 24, 875-881.(2008)
    [ DOI:10.1016/j.bios.2008.07.027 ]
  5. J.-Y. Cheng*, M.-H. Yen, C.-T. Kuo and T.-H. Young, "A transparent cell culture microchamber with variablly controlled concentration gradient generator and flow field rectifier", Biomicrofluidics, 2, 024105.(2008)
    [ DOI:10.1063/1.2952290 ]
  6. Cheng, J.-Y., Yen, M.-H., Hsu, W.-C., Jhang, J.-H. and Young, T.-H. (2007) ITO patterning by a low power Q-switched green laser and its use in the fabrication of a transparent flow meter. J. Micromech. Microeng., 17, 2316-2323
    [ DOI:10.1088/0960-1317/17/11/019 ]
  7. Yen, M.-H., Cheng, J.-Y., Wei, C.-W., Chuang, Y.-C. and Young, T.-H. (2006) Rapid cell-patterning and microfluidic chip fabrication by crack-free CO2 laser ablation on glass. Journal of Micromechanics and Microengineering, 16, 1143-1153.
  8. Wei, C.-W., Cheng, J.-Y. and Young, T.-H. (2006) Elucidating in vitro Cell-Cell Interaction Using a Microfluidic Coculture System. Biomedical Microdevices, 8, 65-71.
  9. Cheng, J.-Y., Yen, M.-H. and Young, T.-H. (2006) Crack-free micromachining on glass using an economic green laser. Journal of Micromechanics and Microengineering, 16, 2420-2424
  10. Wei, C.-W., Young, T.-H. and Cheng, J.-Y. (2005) Electroosmotic mixing induced by non-uniform zeta potential and application for DNA microarray in microfluidic channel (EI). Biomedical Engineering Applications, Basis & Communications, 17, 281-283.
  11. Wei, C.-W., Cheng, J.-Y., Huang, C.-T., Yen, M.-H. and Young, T.-H. (2005) Using a microfluidic device for 1 microliter DNA microarray hybridization in 500 seconds. Nucleic Acids Research Methods, 33, e78. Times cited: 8

    [ DOI:10.1093/nar/gni078 ]
  12. Kang, C.-C., Chang, C.-C., Cheng, J.-Y. and Chang, T.-C. (2005) Simple method in diagnosing cancer cells by a novel fluorescence probe BMVC. J. Chin. Chem. Soc., 52, 1069-1072.
  13. Cheng, J.-Y., Yen, M.-H., Wei, C.-W., Chuang, Y.-C. and Young, T.-H. (2005) Crack-free direct-writing on glass using a low-power UV laser in the manufacture of a microfluidic chip. Journal of Micromechanics and Microengineering, 15, 1147-1156. Times cited: 1, including 1 Research Highlight in Lab-on-Chip, Oct, 2005.
  14. Cheng, J.-Y., Hsieh, C.-J. and Chuang, Y.-C. (2005) Performing microchannel temperature cycling reactions using reciprocating reagent shuttling along radial temperature gradient. The Analyst, 130, 931-940. Times cited: 2, including 1 Research Highlight in Lab-on-Chip, Sep, 2005.
  15. Chou, R.-H., Lin, K.-C., Lin, S.-C., Cheng, J.-Y., Wu, C.-W. and Chang, W.-S.W. (2004) Cost-effective trapezoidal modified Boyden chamber with comparable accuracy to a commercial. Biotechniques, 37, 724-726.
  16. Cheng, J.-Y., Wei, C.-W., Hsu, K.-H. and Young, T.-H. (2004) Direct-write Laser Micromachining and Universal Surface Modification of PMMA for Device Development. Sensors and Actuators B:Chemistry, 99, 186-196. Times cited: 14. Selected in the Prominent Research Accomplishment of Academia Sinica, 2005 (94年中央研究院重要研究成果)
  17. Cheng, J.-Y. and Hsiung, L.-C. (2004) Electrowetting (EW)-Based Valve Combined with Hydrophilic Teflon Microfluidic Guidance in Controlling Continuous Fluid Flow. Biomedical Microdevices, 6, 341-347. Times cited: 1
  18. Cheng, J.-Y., Chen, H.-H., Kao, Y.-S., Kao, W.-C. and Peck, K. (2002) High throughput parallel synthesis of oligonucleotides with 1536 channel synthesizer. Nucleic Acids Research Methods, 30, e93.


  1. “生化反應晶片及其製法” Taiwan Patent filed No.094136433, Feb, 2006.
  2. “雷射無碎裂微加工”, ”Crack-Free Laser Microfabrication”, Taiwan Patent filed, Jul, 2005
  3. “Preparation and Surface Modification of Plastic Microfluidic Chip.”, Cheng, J.-Y. and Wei, C.-W., Patent filed, 2004, United States: 10/705,698
  4. “Microarray biochemical reaction device”, US Patent filed, No. 11.249,449, Feb, 2006
  5. “流體驅動裝置及其製法”, “Apparatus and fabrication of microfluidic driving device”, Patent Granted, Taiwan Patent No. 258456, Jul, 2006.
  6. “Apparatus and Methods for Chemical Synthesis”, Konan Peck, Ji-Yen Cheng, 2002, Patent Granted, US Pat. No.6,867,050.